KMID : 1161420210240040436
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Journal of Medicinal Food 2021 Volume.24 No. 4 p.436 ~ p.440
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Acute Effects of Turmeric Extracts on Knee Joint Pain: A Pilot, Randomized Controlled Trial
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Calderon-Perez Lorena
Llaurado Elisabet Companys Judit Pla-Paga Laura Boque Noemi Puiggros Francesc Valls Rosa-M. Pedret Anna Llabres Josep Manuel Arola Lluis Sola Rosa
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Abstract
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Turmeric extracts (TEs) have been shown to be suitable as a pain treatment for human joint arthritis. In a pilot, randomized clinical trial, 68 individuals with mild/moderate knee joint pain (KJP) consumed a new formulation of water-soluble TEs and insoluble curcuminoids (B-Turmactive¢ç) or brewer's yeast as a placebo for 1 week. Our hypothesis was that B-Turmactive would have a short-term analgesic effect on KJP measured by the self-reported Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). After 3 days and 1 week, both treatments reduced pain when walking on a flat surface (P?.01), going up or down stairs (P?.001), and sitting or lying (P?.05), but only B-Turmactive reduced pain at night while in bed and in an upright standing position (P?.01). Concerning global KJP, it was reduced by both treatments after 3 days and 1 week of the intervention (P?.001), being less with B-Turmactive after 1 week (P?=?.012 vs. 3 weeks). Although no intertreatment differences were observed, only B-Turmactive decreased high-sensitivity C-reactive protein levels (P?=?.045) at 1 week, which indicates a prompt analgesic effect mediated by a decrease in inflammatory status.
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KEYWORD
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knee joint pain, turmeric extracts, curcuma longa, Brewer's yeast, painkiller
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